George Washington Crile, anoci-association, and pre-emptive analgesia

George Washington Crile, anoci-association, and pre-emptive analgesia.

Pre-emptive analgesia.

Transmission of pain signals evoked by tissue damage leads to sensitization of the peripheral and central pain pathways. Pre-emptive analgesia is a treatment that is initiated before the surgical procedure in order to reduce this sensitization. Owing to this 'protective' effect on the nociceptive system, pre-emptive analgesia has the potential to be more effective than a similar analgesic treat...

Pre - Emptive Extradural Analgesia

5. Mallett SV, RoUes K, Cox D, Burroughs A, Hunt B. Intraopcrative use of aprotinin (Trasylol) in orthotopic liver transplantation. Transplantation Proceedings 1991; 23: 19311932. 6. Thomson JF, Roath OS, Francis JL, Webster JHM, Chant ADB. Aprotinin in peripheral vascular surgery. Lancet 1990; 335:911. 7. Kobrinsky NL, Letts MR, Patcl LR, l-Desamino-8-D arginine vasopressine (Desmopressin) dec...

Vitreoretinal surgery: pre-emptive analgesia.

AIM Vitrectomies are performed either under general anesthesia (GA), local anesthesia (LA), or a combination of both. Postoperative pain is expected to be less in patients with LA because of prolonged action of the local anaesthetic. Pre-emptive analgesia is based on the idea that analgesia initiated before a nociceptive event will be more effective than analgesia commenced afterwards. The auth...

Pre-emptive analgesia: importance of timing.

pain has been dominated by an outdated conceptualization of pain.1 Pain is viewed as the end-product of a passive transmission system that faithfully transmits a peripheral signal to the spinal cord and on up to a pain centre in the brain. This view has led to an approach of managing postoperative pain that does not provide adequate control of pain, in part, because it focuses on treating the p...